Auo trial ah 0194 by the german testicular cancer study group. If you just found out that you or your child has a germ cell tumor, you may have a lot of questions about what it means and what comes next. Mixed germ cell tumors represent 4060% of testicular tumors, they can occur in undescended testicles or not, and extratesticular sites. Treatment for testicular cancer is based mainly on the type and stage of the cancer.
Albers p, siener r, krege s, et al randomized phase iii trial comparing retroperitoneal lymph node dissection with one course of bleomycin and etoposide plus cisplatin chemotherapy in the adjuvant treatment of clinical stage i nonseminomatous testicular germ cell tumors. Nccn evidencebased cancer guidelines, oncology drug. A case of a testicular germ cell tumour arises, an unusual neoplasia characterized by the. Among the different stages of germ cell tumors, pure seminomas tend to be treated one way, and nonseminomas and mixed germ cell tumors are treated another way. Nevertheless, our ability to predict metastases in earlystage disease and responders to chemotherapy in advanced disease is limited. Pdf glypican 3 gpc3, a membranebound heparin sulfate proteoglycan, may play a role in promoting embryonic cell growth and differentiation. Cc clinical ractice uielines in ncolog cc uielines. Treatment options for testicular cancer, by type and stage. An overview of testicular germ cell tumors request pdf.
What is the regimen for vip in the treatment of testicular. Treatment options for cisplatinresistant disease are sparse. We would like to show you a description here but the site wont allow us. These tumors are rare, making up less than 5 percent of testis cancers, and have an excellent prognosis if surgically resected. Leydig cells make the male hormone testosterone and are most often. Testicular cancer represents 5% of urological tumours affecting mostly younger males. Testicular germ cell tumors tgct are a model for curable cancer due to exquisite chemosensitivity and incorporation of multimodal therapy. Seminomas are the most frequent kind of testicular germ cell tumors tgcts, accounting for 50% of tumor diagnosis in young men, whereas nonseminomas account for. There are many kinds of germ cell tumors and only some. Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. Testicular cancer is the most common tumor in young adult men 3, and the majority of cases occur in young men aged 1535 1,4. Tumors can also develop from the supportive tissues around the germ cells in the testicle. This clinical practice guideline for testicular seminoma and nonseminoma features epidemiology of these rare malignancies in young men, the diagnosis, management of the primary tumour, postorchiectomy staging and risk assessment, treatment recommendations, late relapse, late toxicity and followup. The aim of these guidelines is to present the current evidence for the diagnosis and treatment of patients with cancer of the testis.